|
|
2-oxoisovalerate + CoA + NAD+ <=> isobutyryl-CoA + CO2 + NADH
|
1.2.1.25
branched-chain alpha-keto acid dehydrogenase system
1.2.4.1
pyruvate dehydrogenase (acetyl-transferring)
1.2.4.4
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
2.7.11.4
[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase
|
–
–
–
–
|
BM
|
|
BRENDA:
BR36775
KEGG:
R01210
MetaCyc:
1.2.1.25-RXN
SABIO-RK:
1443;
1814
|
|
|
|
2-oxoisovalerate + CoA + oxidized_ferredoxin <=> isobutyryl-CoA + CO2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+
|
1.2.7.7
3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
|
–
|
MK
|
|
BRENDA:
BR48034
KEGG:
R07160
MetaCyc:
1.2.7.7-RXN
|
|
|
|
isobutyryl-CoA <=> butyryl-CoA
|
5.4.99.13
isobutyryl-CoA mutase
5.4.99.64
2-hydroxyisobutanoyl-CoA mutase
|
–
–
|
|
|
BRENDA:
BR48371
KEGG:
R01181
MetaCyc:
ISOBUTYRYL-COA-MUTASE-RXN
SABIO-RK:
1418
|
|
|
|
isobutyryl-CoA + malonyl-CoA + H+ <=> phloroisobutyrophenone + CO2 + CoA
|
2.3.1.156
phloroisovalerophenone synthase
2.3.1.220
2,4,6-trihydroxybenzophenone synthase
|
–
–
|
M
|
|
BRENDA:
BR52116
KEGG:
R11584
MetaCyc:
RXN-7805
|
|
|
|
ATP + Isobutyrate + CoA <=> diphosphate + AMP + isobutyryl-CoA
|
6.2.1.1
acetate---CoA ligase
6.2.1.2
medium-chain acyl-CoA ligase
6.2.1.44
3-(methylthio)propionyl---CoA ligase
|
–
–
–
|
M
|
|
BRENDA:
BS195
MetaCyc:
RXN-18447
|
|
|
|
Isobutyraldehyde + CoA + NAD+ <=> isobutyryl-CoA + NADH + H+
|
1.2.1.10
acetaldehyde dehydrogenase (acetylating)
|
–
|
|
|
BRENDA:
BS258013
MetaCyc:
RXN-13671
|
|
|
|
isobutyryl-CoA + H2O <=> Isobutyrate + CoA + H+
|
3.1.2.20
acyl-CoA hydrolase
|
–
|
M
|
|
BRENDA:
BS401183
MetaCyc:
RXN-21793
|
|
|
|
isobutyryl-CoA + enzyme_N6-(dihydrolipoyl)lysine <=> CoA + enzyme_N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine
|
2.3.1.168
dihydrolipoyllysine-residue (2-methylpropanoyl)transferase
|
–
|
K
|
|
BRENDA:
BR48046
KEGG:
R02662
|
|
|
|
isobutyryl-CoA + acceptor <=> methacryloyl-CoA + reduced_acceptor
|
1.3.8.1
short-chain acyl-CoA dehydrogenase
1.3.8.7
medium-chain acyl-CoA dehydrogenase
1.3.99
1.3.99.12
2-methylacyl-CoA dehydrogenase
|
–
–
–
–
|
K
|
|
BRENDA:
BS258777
KEGG:
R02661
|
|
|
|
ATP + Isobutyrate + CoA <=> ADP + phosphate + isobutyryl-CoA
|
6.2.1.13
acetate---CoA ligase (ADP-forming)
6.2.1.B11
|
–
–
|
|
|
BRENDA:
BS167
SABIO-RK:
14346
|
|
|
|
Isobutyrate + acetoacetyl-CoA <=> isobutyryl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358830
SABIO-RK:
11111
|
|
|
|
isobutyryl-CoA + dihydrolipoamide <=> CoA + S-2-methylpropanoyldihydrolipoamide
|
2.3.1.168
dihydrolipoyllysine-residue (2-methylpropanoyl)transferase
|
–
|
|
|
BRENDA:
BS359554
SABIO-RK:
2558
|
|
|
|
isobutyryl-CoA <=> Branched_chain_fatty_acid
|
not assigned
|
–
|
K
|
|
KEGG:
R02663
|
|
|
|
isobutyryl-CoA + 5 methylmalonyl-CoA + 7 malonyl-CoA + 9 NADPH + 9 H+ <=> 6,8a-Seco-6,8a-deoxy-5-oxoavermectin_''''2b''''_aglycone + 12 CO2 + 13 CoA + 5 H2O + 9 NADP+
|
not assigned
|
–
|
K
|
|
KEGG:
R06482
|
|
|
|
isobutyryl-CoA + 5 methylmalonyl-CoA + 7 malonyl-CoA + 9 NADPH + 9 H+ <=> 6,8a-Seco-6,8a-deoxy-5-oxoavermectin_''''1b''''_aglycone + 12 CO2 + 13 CoA + 6 H2O + 9 NADP+
|
not assigned
|
–
|
K
|
|
KEGG:
R06483
|
|
|
|
isobutyryl-CoA + 3 malonyl-CoA <=> 8-Methyl-6-nonenoic_acid
|
not assigned
|
–
|
K
|
|
KEGG:
R09090
|
|
|
|
N-Demethyl-desepoxymaytansinol + isobutyryl-CoA <=> N-Demethyl-desepoxyansamitocin_P-3 + CoA
|
not assigned
|
–
|
K
|
|
KEGG:
R09854
|
|
|
|
isobutyryl-CoA + [apo_BCAA_dehydrogenase_E2_protein]_N6-dihydrolipoyl-L-lysine <=> [apo_BCAA_dehydrogenase_E2_protein]_N6-S-[2-methylpropanoyl]dihydrolipoyl-L-lysine + CoA
|
2.3.1.168
dihydrolipoyllysine-residue (2-methylpropanoyl)transferase
|
–
|
M
|
|
MetaCyc:
2.3.1.168-RXN
|
|
|
|
isobutyryl-CoA + oxidized_electron_transfer_flavoprotein + H+ <=> methacryloyl-CoA + reduced_flavodoxin
|
1.3.8.5
2-methyl-branched-chain-enoyl-CoA reductase
|
–
|
M
|
|
MetaCyc:
MEPROPCOA-FAD-RXN
|
|
|
|
DELTA2,5-3,4,4-trimethylpimeloyl-CoA + CoA + H2O + H+ + acceptor <=> isobutyryl-CoA + acetyl-CoA + reduced_acceptor
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-13045
|
|
|
|
isobutyryl-CoA + malonyl-[acyl-carrier_protein] + H+ <=> 4-methyl-3-oxopentanoyl-[acp] + CoA + CO2
|
2.3.1.dr
|
–
|
M
|
|
MetaCyc:
RXN-21611
|
|
|
|
malonyl-[acyl-carrier_protein] + isobutyryl-CoA + NADPH + H+ <=> 8-Methyl-6-nonenoate + [acyl-carrier_protein] + CoA + H2O + NADP+
|
2.3.1
|
–
|
M
|
|
MetaCyc:
RXN-8926
|
|
|
|
sucrose-2-(2-methyl)butyryl-4-(2-methyl)butyryl-3-(4-methyl)pentanoate + isobutyryl-CoA <=> sucrose-2-(2-methyl)butyryl-4-(2-methyl)butyryl-3-(4-methyl)pentanoyl-6-isobutyrate + CoA
|
2.3.1
|
–
|
|
|
MetaCyc:
RXN18C3-109
|
|
|
|
sucrose-2-(2-methyl)butyryl-4-(2-methyl)butyryl-3-(5-methyl)hexanoate + isobutyryl-CoA <=> sucrose-2-(2-methyl)butyryl-4-(2-methyl)butyryl-3-(4-methyl)hexanoyl-6-isobutyrate + CoA
|
2.3.1
|
–
|
|
|
MetaCyc:
RXN18C3-111
|
|
|
|
sucrose-2-(2-methyl)butyryl-4-(2-methyl)butyryl-3-(6-methyl)heptanoate + isobutyryl-CoA <=> sucrose-2-(2-methyl)butyryl-4-(2-methyl)butyryl-3-(6-methyl)heptanoyl-6-isobutyrate + CoA
|
2.3.1
|
–
|
|
|
MetaCyc:
RXN18C3-113
|
|
|
|
sucrose + isobutyryl-CoA <=> 4-(isobutanoyl)sucrose + CoA
|
2.3.1
|
–
|
M
|
|
MetaCyc:
RXN18C3-24
|
|
|
|
4-(3-methylbutanoyl)sucrose + isobutyryl-CoA <=> 3-isobutanoyl-4-(3-methylbutanoyl)sucrose + CoA
|
2.3.1
|
–
|
M
|
|
MetaCyc:
RXN18C3-29
|
|
|
|
4-(3-methylbutanoyl)sucrose + isobutyryl-CoA <=> 2-isobutanoyl-4-(3-methylbutanoyl)sucrose + CoA
|
2.3.1
|
–
|
M
|
|
MetaCyc:
RXN18C3-43
|
|
|
|
3-dodecanoyl-4-(3-methylbutanoyl)sucrose + isobutyryl-CoA <=> 3-dodecanoyl-3''-isobutanoyl-4-(3-methylbutanoyl)sucrose + CoA
|
2.3.1
|
–
|
M
|
|
MetaCyc:
RXN18C3-49
|
|
|
|
isobutyryl-CoA + L-arginine <=> N-[(4S)-4-amino-6-methyl-5-oxoheptyl]guanidine + CO2 + CoA
|
2.3.1.47
8-amino-7-oxononanoate synthase
|
–
|
|
|
BRENDA:
BS455795
|
|
|
|
isobutyryl-CoA + phosphate <=> isobutanoyl_phosphate + CoA
|
2.3.1.19
phosphate butyryltransferase
|
–
|
|
|
BRENDA:
BS320617
|
|
|
|
2-oxoisovalerate + CoA + Oxidized_benzyl_viologen <=> isobutyryl-CoA + CO2 + reduced_benzyl_viologen
|
1.2.7.7
3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
|
–
|
|
|
BRENDA:
BS359413
|
|
|
|
isobutyryl-CoA + L-homoserine <=> CoA + O-isobutyryl-L-homoserine
|
2.3.1.31
homoserine O-acetyltransferase
|
–
|
|
|
BRENDA:
BS388943
|
|
|
|
2-oxoisovalerate + H2O + methyl_viologen <=> isobutyryl-CoA + reduced_methyl_viologen + H+
|
1.2.7.8
indolepyruvate ferredoxin oxidoreductase
|
–
|
|
|
BRENDA:
BS442860
|
|
|
|
Isobutyraldehyde + CoA + NAD+ <=> isobutyryl-CoA + NAD+ + H+
|
1.2.1.87
propanal dehydrogenase (CoA-propanoylating)
|
–
|
|
|
BRENDA:
BS423694
|
|
|
|
isobutyryl-CoA + D-glucose_6-phosphate <=> CoA + N-isobutanoyl-D-glucosamine_6-phosphate
|
2.3.1.4
glucosamine-phosphate N-acetyltransferase
|
–
|
|
|
BRENDA:
BS455794
|
|
|
|
acetyl-CoA + Isobutyrate <=> acetate + isobutyryl-CoA
|
2.8.3.1
propionate CoA-transferase
|
–
|
|
|
BRENDA:
BS436983
|
|
|
|
isobutyryl-CoA + [acyl-carrier_protein] <=> CoA + an_isobutyryl-[acyl_carrier_protein]
|
2.3.1.39
[acyl-carrier-protein] S-malonyltransferase
|
–
|
|
|
BRENDA:
BS455798
|
|
|
|
isobutyryl-CoA + malonyl-[acyl-carrier_protein] <=> 3-oxo-4-methyl-pentanoyl-[acyl-carrier_protein] + CoA + CO2
|
2.3.1.180
beta-ketoacyl-[acyl-carrier-protein] synthase III
|
–
|
|
|
BRENDA:
BS380632
|
|
|
|
isobutyryl-CoA + pseudotropine <=> CoA + O-isobutyrylpseudotropine
|
2.3.1.186
pseudotropine acyltransferase
|
–
|
|
|
BRENDA:
BS392287
|
|
|
|
isobutyrylcarnitine + CoA <=> isobutyryl-CoA + carnitine
|
2.3.1.7
carnitine O-acetyltransferase
|
–
|
|
|
BRENDA:
BS321229
|
|
|
|
isobutyryl-CoA <=> 4-hydroxy-6-isopropyl-2-pyrone + 4-hydroxy-6-(3''-methyl-2''-oxopropyl)-2-pyrone + CoA + CO2 + H2O
|
2.3.1.233
1,3,6,8-tetrahydroxynaphthalene synthase
|
–
|
|
|
BRENDA:
BS430271
|
|
|
|
isobutyryl-CoA + glycine <=> CoA + N-isobutyrylglycine
|
2.3.1.71
glycine N-benzoyltransferase
|
–
|
|
|
BRENDA:
BS321261
|
|
|
|
3 malonyl-CoA + isobutyryl-CoA <=> 4 CoA + 2,4,6-trihydroxyisobutyrophenone + 3 CO2
|
2.3.1.220
2,4,6-trihydroxybenzophenone synthase
|
–
|
|
|
BRENDA:
BS454956
|
|
|
|
isobutyryl-CoA + acceptor <=> isobutyr-2-yl-CoA + reduced_acceptor
|
1.3.99.12
2-methylacyl-CoA dehydrogenase
|
–
|
|
|
BRENDA:
BS373485
|
|
|
|
isobutyryl-CoA + acceptor <=> isobutyryl-CoA + reduced_acceptor
|
1.3.8.4
isovaleryl-CoA dehydrogenase
|
–
|
|
|
BRENDA:
BS258766
|
|
|
|
isobutyryl-CoA + phenazine_methosulfate + oxidized_2,6-dichlorophenolindophenol <=> 2-methylpropenoyl-CoA + reduced_acceptor
|
1.3.8.1
short-chain acyl-CoA dehydrogenase
|
–
|
|
|
BRENDA:
BS258794
|
|
|
|
FAD + isobutyryl-CoA <=> methacryloyl-CoA + FADH2
|
1.3.99.12
2-methylacyl-CoA dehydrogenase
|
–
|
|
|
SABIO-RK:
2557
|
|